Mesenchymal Cell Activation by Biomechanical Stimulation and its Clinical Prospects

Mechanotransduction in Chondrocytes

Author(s): Marwan Haddad, Jacob Shapira and Nahum Rosenberg

Pp: 59-64 (6)

DOI: 10.2174/9781681081991116010009

* (Excluding Mailing and Handling)


Mechanical load is the cardinal factor in regulating the metabolic activity of chondrocytes. Chondrocytes are sensitive to load pattern and can adjust their metabolism according to the magnitude and frequency of mechanical stress. Quantity and quality characterization of the chondrocyte response to stress is yet to be revealed and may lead to novel therapeutic methods in preventing and treatment of cartilage degeneration diseases.

Keywords: Cartilage, chondroblat, chondrocyte, ECM, GAG.

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