Frontiers in Anti-Cancer Drug Discovery

Volume: 6

Use of Magnetosomes of Biological Origin, By Magnetic Hyperthermia for the Treatment of Tumors

Author(s): Edouard Alphandéry

Pp: 218-248 (31)

DOI: 10.2174/9781681081496115060009

* (Excluding Mailing and Handling)


This chapter describes a therapy for cancer using iron oxide nanoparticles, called magnetosomes, which are synthesized by magnetotactic bacteria. After intratumoral administration, magnetosomes extracted from magnetotactic bacteria are heated by applying an alternating magnetic field. The heat induces anti-tumor activity. This type of cancer therapy has essentially been developed using chemical nano-particles. Magnetosomes possess a series of advantages as compared with these chemical nanoparticles, such as a larger size and ferromagnetic behavior, which enable them to produce more heat and an arrangement in chains, which prevents aggregation. A preclinical proof of concept of the therapy, carried out on mice bearing MDA-MB231 breast tumors is presented and shows that it is possible to completely eradicate these tumors with the therapy. The latter French company called “Nanobacterie”, has been established in 2008 to develop the therapy.

Keywords: Alternating magnetic field, Cancer, Magnetotactic bacteria, Magnetosomes, Magnetic hyperthermia, Tumor.

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