Women’s Heart and Estrogens

Estrogens and Atherogenesis

Author(s): Genovefa D. Kolovou

Pp: 3-30 (28)

DOI: 10.2174/9781681081120115010003

* (Excluding Mailing and Handling)


In the 21st century, cardiovascular disease has become a global cause of morbidity and a main contributor to mortality in most countries, regardless of the important actions which have been endorsed for primary and secondary prevention. Concerning women's cardiovascular mortality, in all age groups it is more frequent and even greater than it is due to breast cancer. In this chapter, the stages of atherogenesis, the factors that induce atherogenesis (environmental and genetic), the effects of estrogens on the stages of atherogenesis, and finally, the effects of estrogens on those components will be analyzed.

Keywords: Apolipoprotein E gene polymorphism, Atherogenesis, Cholesterol, Cholesteryl ester transfer protein gene polymorphism, Estrogens, Estrogen receptor gene polymorphisms, Familial hypercholeste-rolemia, Sitosterolemia.

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