Recent Advances in Medicinal Chemistry

Volume: 1

HPLC and its Essential Role in the Analysis of Tricyclic Antidepressants in Biological Samples

Author(s): V.F. Samanidou, M.K. Nika and I.N. Papadoyannis

Pp: 332-380 (49)

DOI: 10.2174/9781608057962114010014

* (Excluding Mailing and Handling)


HPLC is discussed as an essential tool for the analysis of tricyclic antidepressants in biological samples, providing clinicians with efficient fast and reliable methods to define individual optimum therapeutic concentrations in treatment of depressions. Additional information on mechanism of action, structure activity relationship and metabolism is provided. Sample preparation issues are discussed.

Keywords: Biological fluids, HPLC, monitoring, medicinal chemistry, tricyclic antidepressants.

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