Recent Advances in Medicinal Chemistry

Volume: 1

Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors?

Author(s): Ivana Campia, Sophie Doublier, Elisabetta Aldieri, Amalia Bosia, Dario Ghigo and Chiara Riganti

Pp: 209-245 (37)

DOI: 10.2174/9781608057962114010010

* (Excluding Mailing and Handling)


Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.

Keywords: Cancer, chemotherapy, isoprenylation, rho GTPases, statins.

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