Advances in Biomedical Sciences and Engineering

In Vivo Studies of α-Particle Radiation Effects Using Zebrafish Embryos

Author(s): Kwan Ngok Yu and Shuk Han Cheng

Pp: 263-283 (21)

Doi: 10.2174/978160805040610901010263

* (Excluding Mailing and Handling)

Abstract

A brief review on the progress on in vivo studies of α-particle radiation effects using zebrafish embryos was given in this chapter. The zebrafish, Danio rerio, a small vertebrate from Southeast Asia, has become a preferred model for studying human disease. The main challenges of these α-particle radiobiological experiments included quantification of alpha-particle dose. In particular, specially etched polyallyldiglycol carbonate (PADC) films, which are a kind of solid-state nuclear track detector (SSNTD), were chosen as support substrates for zebrafish embryos. The fabrication procedures were outlined. Methods for quantification of alpha-particle dose were described. Preliminary in vivo studies on the radiation effects of alpha particles in zebrafish embryos were briefly reviewed. These included results on low-dose radiation effects of α particles as well as results on alpha-particle-induced bystander effects between zebrafish embryos in vivo.

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