Advances in Biomedical Sciences and Engineering

Synthesis and Properties of Nano-Hydroxyapatite/ Polymer Nanocomposites for Bone Tissue Engineering

Author(s): Sie Chin Tjong

Pp: 82-142 (61)

Doi: 10.2174/978160805040610901010082

* (Excluding Mailing and Handling)

Abstract

Hydroxyapatite (HA) is the main mineral constituent of human bones. HA nanocrystals can be synthesized using a variety of wet solution methods including chemical precipitation, hydrothermal, sol-gel, micro- and nano-emulsion. HA nanocrystals synthesized from the chemical precipitation process generally exhibit plate-like morphology. They tend to self-organize into an ordered structure in the presence of biopolymers. The self-assembled HA-polymer nanocomposites simulate the hierarchical structure of human bone at a fundamental level. Such biomimetic nanocomposites favor osteoblast adhesion and proliferation, thereby stimulating new bone growth. Proper understanding of the biomineralization of self-assembled structures is needed for designing high performance polymer nanocomposites in bone tissue engineering.


Keywords: Bone, hydroxyapatite, nanocrystal, polymer, precipitation, self-assembly, biocompatibility, biomimetic structure, scaffold, electrospinning

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