Frontiers in Drug Discovery

Volume: 1

Risks and Benefits Associated with High Therapeutic Doses of Erythropoiesis Stimulating Agents

Author(s): Sandra Ribeiro, Elísio Costa, Flávio Reis and Alice Santos-Silva

Pp: 81-97 (17)

DOI: 10.2174/9781608057474113010008

* (Excluding Mailing and Handling)


The introduction of erythropoiesis stimulating agents (ESAs) for the treatment of anemia in chronic kidney disease patients and chemotherapy-induced anemia associated with non-myeloid malignancies, improved the quality of life in these patients. Recently, several pleiotropic effects have been attributed to ESAs, especially under doses higher than the doses used to treat anemia. However, recent studies have raised some concerns about the use of high doses in patients that do not respond properly to the therapy. To use the pleiotropic actions of ESAs new molecules have been developed, that do not present hematopoietic actions. In this book chapter, we present a review of the risks and benefits associated with the use of high ESAs. We also present the recent proposal for new agents based on the EPO molecule and actions.

Keywords: Anemia, Erythropoiesis stimulating agents, ESAs benefits, ESAs risks, High doses, ESAs pleiotropic effects.

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