Abstract
The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anticancer agents. These compounds belong to the tripentone family and are based on 9Hpyrrolo[ 1,2-a]indol-9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.
Keywords: Tripentone, pyrrolizinone, pyrroloindolone, thiophene, cancer, pyrrole , heterocycles, clauson-kaas, acylation, ring closure.
About this chapter
Cite this chapter as:
Christophe Rochais, Sylvain Rault, Patrick Dallemagne ;Tripentones: A Promising Series of Potent Anti-Cancer Agents, Advances in Anticancer Agents in Medicinal Chemistry (2013) 2: 313. https://doi.org/10.2174/9781608054961113020009
DOI https://doi.org/10.2174/9781608054961113020009 |
Print ISSN 2214-4331 |
Publisher Name Bentham Science Publisher |