Mucins – Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins

Secreted Mucins: Covert Functions

Author(s): Joseph Z. Zaretsky and Daniel H. Wreschner

Pp: 547-568 (22)

DOI: 10.2174/9781608054541113010015

* (Excluding Mailing and Handling)


Functions that potentially can be performed by secreted mucins have been analyzed by bioinformatics using the Motifscan and Eukaryotic Linear Motif (ELM) tools and STRING 9.0 interaction network. A number of potentially important motifs were discovered and possible functional partners of the secreted mucin glycoproteins were predicted. A new role of galactin-3 in physiological transformation of the intestinal mucus gel layers is proposed.

Keywords: Secreted mucins, galectin-3, bioinformatics.

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