Mucins – Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins

Mucin MUC9

Author(s): Joseph Z. Zaretsky and Daniel H. Wreschner

Pp: 425-451 (27)

DOI: 10.2174/9781608054541113010013

* (Excluding Mailing and Handling)


The MUC9/OGP gene encodes the oviduct-specific secreted glycoprotein, MUC9/OGP. This glycoprotein is a member of two protein superfamilies: the mucin protein superfamily and the glycosyl hydrolase 18 one. It contains 11 exons and 10 introns. Although MUC9/OGP genes cloned from different mammals display the same structure, species-specific features have been observed for each gene. The mechanisms of transcriptional regulation of the MUC9/OGP gene have been investigated. Comparative studies of the cloned 5’-flanking promoter sequences showed that the homologous MUC9/OGP genes demonstrate conservation of transcription factor-specific cis-elements, but their individual promoters bear species-specific features that determine species-specific expression of a given MUC9/OGP gene. The biosynthetic pathway leading to production of the mature MUC9/OGP glycoprotein has been identified. Overt and covert functional potentials of the MUC9/OGP mucin are discussed.

Keywords: MUC9/OGP, promoter, biosynthesis, domain structure, functions.

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