Mucins – Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins

Mucin MUC8

Author(s): Joseph Z. Zaretsky and Daniel H. Wreschner

Pp: 418-424 (7)

DOI: 10.2174/9781608054541113010012

* (Excluding Mailing and Handling)


Glycoprotein MUC8, one of the less studied mucins, belongs to the group of soluble mucins. Its cDNA is only partially cloned. Like other mucins, MUC8 has a tandem repeat containing domain, but in contrast to other mucins, which have, as a rule, only one type of repeats, the MUC8 mucin has two types of repeats: one of 13 amino acids and another one containing 41 amino acid residues. The MUC8 gene is localized on human chromosome 12q24.3. MUC8 mucin appears to serve a ciliated cell marker. Regulation of MUC8 gene expression has been studied and some regulatory pathways have been identified. MUC8 mucin plays a major role in the airway mucosa and its over-expression and hypersecretion are associated with airway inflammatory diseases.

Keywords: MUC8, mucin, glycoprotein, tandem repeats, transcriptional regulation.

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