Mucins – Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins

Gel-Forming Mucin MUC19

Author(s): Joseph Z. Zaretsky and Daniel H. Wreschner

Pp: 387-397 (11)

DOI: 10.2174/9781608054541113010010

* (Excluding Mailing and Handling)


The mucin MUC19 is a recently discovered member of the gel-forming mucin family. At present, limited information is available regarding its structure and functions. This chapter covers several issues: the evolutionary connection between MUC19 and other gel-forming mucin genes, domain structure of the MUC19 mucin glycoprotein, and specific features of the mouse Smgc/Muc19 mRNA transcription and splicing. Some recent data regarding human MUC19 and mouse Muc19 expression in embryonic development and in adult tissues are presented, and the possible role of MUC19 in physiology of the eye and middle ear are discussed.

Keywords: MUC19, Muc19, Smgc/Muc19, domain structure, splicing, expression.

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