Mucins – Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins

Secreted Mucins

Author(s): Joseph Z. Zaretsky and Daniel H. Wreschner

Pp: 29-43 (15)

DOI: 10.2174/9781608054541113010005

* (Excluding Mailing and Handling)


The group of secreted mucins has eight members: five genes encode the gelforming mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC19) and three genes encode the soluble mucins (MUC7, MUC8 and MUC9). Gel-forming mucins share structural and evolutionary features with von Willibrand Factor. Soluble mucins differ from gel-forming mucins in that the former all do not have the von Willibrand Factor specific domains while mucin specific tandem repeat-containing domain is a common feature of all secreted mucins. Genes encoding the soluble mucins are located at different chromosomes, whereas all gel-forming mucin genes except MUC19 are clustered on chromosome locus 11p15.5 and the MUC19 gene is located on chromosome 12. Structural aspects and functions of the secreted mucins are discussed.

Keywords: Secreted mucins, classification, MUC2, MUC5AC, MUC5B, MUC6, MUC19, MUC7, MUC8, MUC9, chromosomal localization.

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