Surface Tailoring of Inorganic Materials for Biomedical Applications

New Trends in Bone Tissue Engineering Scaffolds: Hierarchically Porous Glass and Glass-Ceramic Structures

Author(s): Francesco Baino and Chiara Vitale Brovarone

Pp: 376-391 (16)

DOI: 10.2174/978160805462611201010376

* (Excluding Mailing and Handling)


Biomaterial choice and porosity features play a crucial role in scaffolds design. Bioactive glasses are ideal candidates for manufacturing bone tissue engineering scaffolds as they can bond to bone and stimulate bone cells towards osteogenesis. A 3-D network of highly interconnected macropores is essential to allow cells migration into the scaffolds, as well as the in vivo vascularization of the implant. An ordered structure of nanopores can impart an added value to the scaffold, enhancing its bioactive properties and providing drug uptake/release abilities to the system. This chapter highlights the great potential carried by hierarchical glass scaffolds, exhibiting pore scales from the meso- to the macro-range, and their impact in the field of bone tissue engineering.

Keywords: Scaffolds, bioactive glass, macropores, mesopores, bone repair.

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