Nephrology and Clinical Chemistry: The Essential Link

New Biomarkers in Acute Kidney Injury

Author(s): Sachin S. Soni, Sonali S. Saboo, Anuradha Raman, Rajasekara M. Chakravarti, Vikranth Reddy, Rupesh Pophale, Ashish S. Bhansali

Pp: 49-57 (9)

DOI: 10.2174/978160805333911201010049

* (Excluding Mailing and Handling)


Acute Kidney Injury (AKI) is increasing to epidemic proportions. Currently available diagnostic tools are less sensitive to diagnose AKI early. Early diagnosis and risk stratification are necessary for prompt therapy and preventing progression of the disease. Finding a reliable, early, reproducible, economical and accurate biomarker for AKI is a top research priority. Many urinary and serum proteins have been intensively investigated as possible early biomarkers of AKI and some of them show great promise. This topic reviews some of the emerging biomarkers of AKI.

Keywords: Acute kidney injury, cystatin C, KIM-1, NGAL, interleukin 18

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