In recent decades, travel and tourism have come to represent a major economic growth sector. To better understand the impact of tourism activity, research on tourism development is undertaken in various fields, involving both theoretical and applied models. The aim of this chapter is to establish a method for analysing the impact of regional tourism development and the associated environmental consequences. The method employed here uses an input-output model with income generated by the tourism sector and emissions released into the atmosphere. The model is applied to the Italian region of Campania, an area with high cultural value, and is used to calculate the emission multipliers of regional activities and to simulate changes in tourist demand and its subsequent effects on regional income and regional emissions.