Abstract
Cancer remains a leading cause of death in the human population worldwide. Both genetic and environmental factors are involved in the development of cancer. Recent work also demonstrates a critical role for reactive oxygen and nitrogen species (ROS/RNS) in multistage carcinogenesis. This chapter examines the oxidative stress mechanism of carcinogenesis as well as antioxidant-based modalities for cancer intervention. The chapter also discusses ROS as a potential tumor killing modality in cancer therapy.
Keywords: Antioxidant intervention, Cancer, Carcinogens, Initiation, Multistage carcinogenesis, Oxidative stress, Progression, Promotion, Reactive nitrogen species, Reactive oxygen species.
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