Laser Therapy has been used as a therapeutic modality for many years and has yet to become a standard of care. This modality has great potential to be used in the clinic for the reduction of pain, inflammation and to aid in the healing process. For years many studies have been done showing the benefits of laser therapy but implementation of this technology into clinically successful products has been lagging behind. This chapter will briefly review the science behind laser therapy, the traditional systems which were used and new technologies, Class IV lasers, now being used to treat injuries seen in the work place. New advances in this technology are being made which are leading to improved and consistent clinical outcomes. The mechanisms of action for pain relief, reduction of edema and tissue healing will be presented as well as important parameters to use in order to succeed when choosing this exciting therapeutic modality. Included are brief reviews of laser therapy when treating epicondylitis, carpal tunnel syndrome, neck and back pain as well as in post surgical rehabilitation applications. Laser therapy is a tool which can have great benefit when treating both acute stage injuries as well improving some chronic conditions.