Protein Misfolding Disorders: A Trip into the ER

Heritable Neurodevelopmental Disorders and Endoplasmic Reticulum Stress

Author(s): Takashi Momoi and Eriko Fujita

Pp: 88-93 (6)

DOI: 10.2174/978160805013010901010088

* (Excluding Mailing and Handling)


The molecular pathogenesis of heritable neurodevelopmental disorders, including autism spectrum disorder (ASD) and speech-language disorder, is not well understood; although, several mutations in genes encoding neuroligin and FOXP2 have been identified. Here, we evaluate the relationship between the protein quality control system of the endoplasmic reticulum (ER) and the molecular pathogenesis of these disorders.

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