Dysbiosis in Acute Kidney Injury and Chronic Kidney Disease

Pp: 273-284 (12)

* (Excluding Mailing and Handling)

Abstract

During acute kidney injury (AKI) and chronic kidney disease (CKD), dysbiosis is induced by mechanisms that alter intestinal homeostasis, leading to a persistent proinflammatory response. This alteration in the intestinal microbiota may regulate immunity, inflammation, and nutrition in patients with AKI and CKD. However, the therapies proposed to reestablish the microbiome balance remain limited and have not shown a benefit. It is possible to use different strategies to modulate the gut microbiota balance to improve kidney function in different renal diseases. Therefore, strategies can be used in combination with available treatment. Nevertheless, it is important to note that individual factors, comorbidities, medications, diet, and lifestyle limit current therapies. Thus, personalized strategies are needed, along with continued research, to achieve outcomes by altering the microbiome and its effects on the progression of kidney disease.

Keywords: Acute kidney injury, Chronic kidney disease, Gut microbiota, Microbiome, Prebiotics, Probiotics.

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