Epigenetics in Renal Diseases

Pp: 213-234 (22)

* (Excluding Mailing and Handling)

Abstract

AKI and CKD have been described as interconnected syndromes as CKD predisposes to AKI, and AKI, in turn, may accelerate CKD progression. Thus, they are considered as an integrated clinical syndrome. AKI and CKD remain incompletely understood. It is well known that environmental and genetic factors are involved in the process. Long-term environmental effects lead to alterations in gene expression, specifically epigenetic changes. Epigenetic mechanisms that might integrate these interactions include chromatin modification, DNA methylation and demethylation, covalent modifications of histones: methylation, acetylation, and crotonylation, and the expression of various non-coding RNAs. Recent advances in epigenetics and diagnostic tools have made the study of kidney dysfunction more efficient, as well as technological achievements that have allowed us to improve our understanding of epigenetics on the physiological and pathological state of the kidney.

Keywords: Acetylation, Chromatin, Crotonylation, Histones, Methylation.

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