Abstract
Angiogenesis plays a pivotal role in progression of both solid and hematologic tumors. We have focused on multiple myeloma (MM) and its bone marrow stromal cells which are not only a support for tumor cell survival, but also active inducers of angiogenesis by releasing a broad number of angiogenic cytokines. Also, stromal cells such as macrophages and mast cells can participate in blood vessels formation in MM through other processes, such as a vasculogenic mimicry. Finally, it has been discovered that hematopoietic stem and progenitor cells (HSPCs) are involved in the vasculogenesis of MM.
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