Recent Advances in Angiogenesis and Antiangiogenesis

Role of Thymidine Phosphorylase/Platelet-Derived Endothelial Cell Growth Factor in Tumor Progression

Author(s): Sandra Liekens

Pp: 67-79 (13)

DOI: 10.2174/978160805004810901010067

* (Excluding Mailing and Handling)


Thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PDECGF) has diverse functions within cells, including the regulation of thymidine levels, the mediation of angiogenesis and apoptosis and the activation of prodrugs of the cancer chemotherapeutic agent 5-fluorouracil (5FU). The purpose of this review is to provide an overview of the pro-tumor effects of TP, including the molecular mechanisms of angiogenesis stimulation and apoptosis inhibition by TP.

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