Theory in the Pathophysiology of Carcinogenesis

Transition Dynamics of In Situ Carcinogenesis

Author(s): Lawrence M. Agius

Pp: 49-51 (3)

DOI: 10.2174/978160805266011101010049

* (Excluding Mailing and Handling)


Transition dynamics conclusively determines the malignant transformation steps that chiefly characterize the objective development of invasive tumor attributes within foci of pre-existing carcinoma in situ, as seen particularly with primary breast neoplasia. The conceptual definition of in situ neoplasia is linked with the developmental dynamics of a field effect in carcinogenesis. It is significant that there is no direct relative involvement in frequency of invasive attributes as considered in terms of the quantification of the in situ change initially present.

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