Muscle Glucose Metabolism in Metabolic Diseases

Abstract

Metabolic diseases such as obesity and diabetes cause disruption of systemic energy metabolism and are major public health problems, with at least 2 billion people affected worldwide. Skeletal muscle tissue makes a substantial contribution to promoting energy efficiency because it remodels cellular size, composition, and function in response to various nutritional changes. However, metabolic diseases such as impaired insulin sensitivity can dynamically affect the metabolism of skeletal muscle. A deeper understanding of myopathology in metabolic disorders may provide clues for therapeutic strategies to promote skeletal muscle health and improve the overall quality of life. This chapter presents how metabolic diseases via cellular mechanisms affect muscle cells and muscle tissue, especially glucose metabolism in skeletal muscle.

Keywords: Diabetes, Glucose, Obesity, Metabolism, Skeletal muscle.

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