Animal Models In Experimental Medicine

Atherosclerosis in Animals

Author(s): Rakan J. Alanazi * .

Pp: 132-142 (11)

DOI: 10.2174/9789815196382124010010

* (Excluding Mailing and Handling)


This chapter on “Animal Models of Atherosclerosis” begins with the description of Atherosclerosis and the use of animal models. When lipids and fibrous tissue accumulate in the arterial wall, a condition known as atherosclerosis develops, which in turn causes the narrowing of the arteries and an increased likelihood of developing cardiovascular problems. Atherosclerosis animal models have been extensively utilized to investigate the disease's pathophysiology and evaluate potential treatments. This study's goal is to provide a brief overview of the analysis of the advantages and disadvantages of the most popular animal models of atherosclerosis, such as mice, rabbits, pigs, nonhuman primates, and dogs. Studies in animals mimicking atherosclerosis often use either high-fat diets or genetic manipulation to learn about the disease. A few of the characteristics of human disease, like lipid accumulation, vascular inflammation, and arterial remodeling, have been successfully reproduced in these models. However, the findings of animal research must be interpreted with caution due to species variations in atherosclerosis onset and progression. In sum, atherosclerosis animal models remain a vital resource for expanding our knowledge of the disease and discovering novel treatment approaches.

Keywords: Animal models, Atherosclerosis, Cardiovascular disease, Genetic manipulation, High-fat diet.

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