The Management of Metastatic Triple-Negative Breast Cancer: An Integrated and Expeditionary Approach

Can We Find A Noninvasive Tool of Precision Medicine That Can Always Be Used For the Individualized Treatment of Women With Breast Cancer?

Author(s): Katarzyna Rygiel * .

Pp: 96-107 (12)

DOI: 10.2174/9789815196023123010009

* (Excluding Mailing and Handling)

Abstract

A constellation of specific personal characteristics of the patients have been described as personomics, which involves an individual patient’s personality type, set of personal values, priorities, preferences, health-related beliefs, goals, economic status, and different life circumstances, which can affect when and how a certain disease (e.g., breast cancer (BC)) can be manifested in a given woman. As a consequence, personomics can be considered to be a novel clinical instrument that is helpful for making a connection between the standard and the emerging, more individualized model of medical care. This plays an essential role in patients diagnosed with the most aggressive and difficult-to-treat malignancies (e.g., BC subtypes, such as triple-negative breast cancer (TNBC). At present, many biological properties in the forms of different “omics” platforms (such as genomics, proteomics, transcriptomics, metabolomics, epigenomics, and pharmacogenomics) have emerged. They have been incorporated into precision medicine. However, to optimally tailor diagnostic and therapeutic approaches to a given patient, the biological characteristics need to be integrated with the personal ones. This chapter aims to address some practical research ideas of personalized medicine, relevant to personomics that can incorporate individual patient issues into the comprehensive therapeutic plan.


Keywords: Breast cancer (BC), Precision medicine, Personomics, Patientcentered approach, Personalized medical care, Triple-negative breast cancer (TNBC).

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