Abstract
The discovery of drugs for human ailments has been greatly attributed to
nature ever since the existence of mankind. Continuous isolation of metabolites from
terrestrial resources leads to a bargaining effect on the synthesis of novel compounds.
Remarkably, marine biotope, one of nature’s resources, accommodates approximately
75% of the global surface. To acclimatize in a marine environment characterized by
unique circumstances that diverge from the individuals present in other habitation,
marine organisms occasionally accumulate structurally distinctive bioactive secondary
metabolites that are deficient in terrestrial organisms. Marine metabolites are currently
employed as the key components in pharmacological research and drug discovery,
acting as drugs and active lead molecules towards the development of novel
antimicrobials. Numerous marine metabolites that are derived from macro and
microorganisms have attained the level of clinical assessment. Hence, marine
environments are considered tools for discovering new antimicrobial agents as they
comprise a vast untapped reservoir of metabolite diversity.
Keywords: Antibiotic resistance, Marine biotope, Marine drugs, Marine metabolomics, Secondary metabolites.