Abstract
Coronavirus pandemics are characterizing the 21st century in itself. In 2002-
03, the first coronavirus SARS-CoV caused Severe Acute Respiratory Syndrome
(SARS); in 2012, the Middle East Respiratory Syndrome (MERS-CoV) made its
appearance, and in 2019, a new human beta coronavirus strain, the SARS-CoV-2 led to
COVID-19 pandemic that took over the entire globe under its rollout. The scientific
research and medical challenges to save lives have revealed the biochemistry and
genetic evolution of an important cycle of the new pathogen, which has steered us to
new preventive and therapeutic approaches to treat SARS-CoV-2. Until now, there is a
scant resource of vaccines available, and therefore, it is very challenging to dose huge
mass around the world. Moreover, there are other various difficulties in producing,
distributing, and storing vaccines; the allopathic drug is always a thrust in this situation.
Various in-silico and in-vitro studies have helped to prove that natural molecules
containing chromene have shown their effectiveness in the treatment of SARS-CoV-2.
Pleiotropic activities and the absence of systemic toxicity of natural chromene and its
derivatives represent potential target compounds in clinical trials to enrich the drug
armament against coronavirus infections. In this chapter, efforts are being made to
discuss the recent investigation of the progress of chromenes in treating SARS-COV-2
virus infection and various treatments involving the possible use of poly-substituted
chromene compounds of modern and natural medicines for the treatment of COVID-19.
Keywords: Anti-viral, Chromene, COVID-19, 3CLpro and PLpro inhibitors, Herbal medicines, Proteases, SARS COV-2.