Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside (Part 1)

Nanocollagen-graphene-antibiotic for Wound Healing

Author(s): Samantha Lo, Ng Wan-Chiew, Ebrahim Mahmoudi and Mohd Fauzi Mh Busra * .

Pp: 239-263 (25)

DOI: 10.2174/9789815123104123010017

* (Excluding Mailing and Handling)

Abstract

Nanotechnology is a greatly advancing field of scientific research due to its largely untapped potential, which may apply to various clinical uses. This book chapter focuses on the potential use of nanocollagen, graphene, and antibiotic components in biomaterial fabrication for wound healing. Nanocollagen is simply regular collagen broken down to the nanometer scale. Its nanocollagen-based biomaterials also conform to the ideals of tissue engineering, which are excellent biocompatibility with a high bioabsorption rate and little to no antigenicity while having an extensively cross-linked structure suitable for cellular growth and metabolism. Nanocollagen can be fabricated through electrospinning, nanolithography, self-assembly, and others. The physiology of wound healing follows specific proceedings, which are haemostasis, inflammation, and remodelling stages. The wound healing process may be improved through the use of nanocollagen biomaterials, together with the addition of graphene and antibiotics. Nanocollagen biomaterials aid in acting as a barrier for the wound against infections while providing collagen in the nanoscale to accelerate healing. The addition of antibiotics into the nanocollagen biomaterial aids in preventing bacterial infection by the inhibition of biofilm formation. Graphene, specifically in its oxide form, also acts as an antibacterial agent while potentially providing mechanical durability to the biomaterial scaffold. Along with the benefits of graphene oxide application in wound healing, its challenges are discussed in this book chapter. With that, this book chapter suggests the beneficial combinatorial factors of nanocollagen, graphene, and antibiotics that can potentially produce biomaterials with strong antibacterial properties while accelerating wound healing.


Keywords: Antibiotic, Biomaterial, Graphene, Nanocollagen, Wound healing.

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