Cancer Genes

Chromosome 5

Author(s): Sayooj Madhusoodanan, Saurav Panicker and Satish Ramalingam * .

Pp: 90-158 (69)

DOI: 10.2174/9789815080292123010008

* (Excluding Mailing and Handling)


Chromosome 5 presents an extensive collection of genes, and includes several cancer-associated ones. The contribution of chromosome 5 in abnormalities is evident through somatic translocations, germline, somatic, and, in some instances, expression of genes. Various syndromes are associated with chromosome 5, such as 5q minus syndrome, leading to the development of acute myeloid leukemia, PDGFRBassociated chronic eosinophilic leukemia contributing to acute myeloid leukemia, and myelodysplastic syndromes. Studies propose that a few genes on chromosome 5 play important roles withinside the increase and department of cells. When chromosome segments are deleted, as in a few instances of AML and MDS, those crucial genes are missing. Without those genes, cells can develop and divide too speedy and in an out-o- -control way. Researchers are trying to perceive the genes on chromosome five that might be associated with AML and MDS.

Keywords: Cellular differentiation, Epigenesis, Follicular variants, Hypermethylation, Intercellular communication, Microsatellite instability, Multi-drug resistance, Polymorphism, Signet-ring cancer, Signal transduction, Translocation.

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