Targeting Potential of Nanocarriers for Efficient Treatment of H. Pylori Infection

Pp: 157-174 (18)

* (Excluding Mailing and Handling)

Abstract

Helicobacter pylori (H. pylori), a prevalent human-specific pathogen, plays a key role in the development of peptic ulcer disease, gastric carcinoma, and gastric mucosa associated lymphoid tissue lymphoma. Once infected, those bacteria reside below the gastric mucosa adherent to the gastric epithelium, and entry of drugs to this target site is very difficult. The bacteria can also acquire resistance to commonly used antimicrobial drugs. Thus, an effective antimicrobial concentration cannot be achieved in the gastric mucous layer or on the epithelial cell surfaces where H. pylori exist and caused inefficient treatment. Such challenges have encouraged researchers into developing some therapies based on nanotechnology.

Keywords: Antibiotics, Gastro-retentive delivery system, H. pylori, Nanoparticles, pH responsive nanoparticles, Herbal approach, Liposomes, Lectins, Nanogels, Nanoparticulate vaccine, Mucoadhesion, Nanocarriers, Nanolipobeads, Polymeric nano-micelles, Receptor mediated targeting.