Patients may show various defects to medications depending on race,
gender, fitness, age, pharmacokinetic and health conditions. To address this challenge,
there is a need to establish personalized, on-demand, programable and smart carriers
that can control drug release with new and robust techniques. Additive manufacturing
(AM) is the key sustenance of digital technology that has been developing and growing
recently. AM offers several opportunities in localized controlled drug delivery systems
(LCDDS), including materials recycling as well as on-site manufacturing, design
freedom and full customization. Moreover, the industrial, biomedical and academic
requests for AM for LCDDS have been continually rising, demonstrating significant
marks for an extensive range of products. This chapter outlines AM approaches and
their functions for LCDDS and describes AM technologies, such as recent advances in
controlled drug release, as well as their processed materials and working principles.
Furthermore, the benefits of 3D printing in the progressions of the LCDDS, the
advantages of 4D printing, the impression of designing and material selection in these
techniques are discussed. Finally, the potentials of AM approaches and their LCDD
applications that designate a promising healthcare future are described.
Keywords: 3D printing, 4D printing, Additive manufacturing, Localized drug delivery, Smart delivery, Stimuli-responsive material.