Therapeutic Use of Plant Secondary Metabolites

Bioactive Compounds as Therapeutic Intervention in Neurodegenerative Diseases

Author(s): N. Suleiman*, I. Bulama and L.S. Bilbis

Pp: 214-237 (24)

DOI: 10.2174/9789815050622122010012

* (Excluding Mailing and Handling)


Neurodegenerative disorders have been implicated as the cause of many devastating diseases that are characterized by gradual loss of susceptible neurons, that are increasingly rising the prevalence of neurodegenerative diseases globally; however, therapeutics for them are lacking. There is an urgent need to develop an effective therapy that can combat the menace caused by disorders of neurodegenerative origin such as Alzheimer's and Parkinson’s diseases, stroke, and traumatic brain injury. Peerreviewed articles were explored for the purpose of this review. Several natural products from medicinal plants have been reported to have phytochemical components with bioactive effects in addition to nutritional value. An appropriate bioactive component is essential for a healthy lifestyle as it plays a significant role in the modulation of neurodegenerative diseases. This review covers the mechanism of action of neurodegenerative disorders and highlights selected classes of bioactive compounds and their effects on neurodegenerative disorders. The use of bioactive compounds in the management of neurodegenerative diseases could solve the problem of the nonavailability of therapy.

Keywords: Bioactive Compounds, Disease, Intervention, Neurodegenerative, Therapeutic.

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