Current Developments in the Detection and Control of Multi Drug Resistance

Methods of Detection of MDR

Author(s): Monish Bisen, Anupam Jyoti and Juhi Saxena * .

Pp: 33-42 (10)

DOI: 10.2174/9789815049879122010006

* (Excluding Mailing and Handling)

Abstract

World health organization (WHO) has acknowledged the problem of multidrug resistance (MDR) bacteria as an endemic and widespread problem globally. MDR in LMICs represents one of the biggest threats to global health and is one of the greatest current challenges in infectious disease research. High mortality/morbidity rates of MDR infections are mainly due to the lack of timely, rapid detection and treatment of the causative pathogen. Molecular mechanism conferring MDR against most common treatment options includes mutations in antibiotics’ susceptible genes at one or many sites. A number of methods, including culture-based, nucleic acid-based amplification of resistance conferring genes, and immunological based assays have been developed to detect MDR. Each method has defined specificity, sensitivity and time around to detect MDR infections in clinical settings. 


Keywords: Antimicrobial Resistance, Detection of MDR, Multi-drug resistance bacteria (MDR), MDR infections

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