Pharmacological and Molecular Perspectives on Diabetes

Role of Antidiabetic Agents which Help Regulate TCF7L2 Variations in Type 2 Diabetes Mellitus

Author(s): Pooja, Dinesh Raj Modi and Madhukar Saxena * .

Pp: 102-109 (8)

DOI: 10.2174/9789815040227122010011

* (Excluding Mailing and Handling)


Type 2 Diabetes Mellitus (T2DM) is the most challenging health issue of the 21st century; it results from a complex interaction between multiple gene and environmental factors. TCF7L2 encodes a transcription factor that is involved in the Wnt signaling pathway that regulates gene expression of pro-glucagon. Effective treatment is needed to properly manage T2DM patients. Currently, 5 major classes of oral pharmacological agents are available for the treatment of T2DM, like metformin, sulfonylureas, meglitinides, thiazolidinedione, and alpha-glucosidase inhibitors

Keywords: TCF7L2, Wnt signaling, Pharmacological agent, Type 2 diabetes mellitus

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