Application of Modern Green Chemistry Methods in the Synthesis of Quinolines, Quinazolines and Quinazolinones

In the last few decades, there is a constant demand for novel bioactive

compounds in all areas of pharmacy and medicine, thus increasing the demands for

their design and synthesis. Quinolines, quinazolines and quinazolinones, highly

bioactive heterocyclic compounds with a nitrogen core, have been employed in many

important drugs nowadays. Their synthesis often includes an enormous amounts of

different hazardous organic solvents, catalysts, as well as energy consumption. In the

last two decades, there is a growing interest in the application of different green

chemistry methods in different research areas, including synthesis. This chapter

describes their application in the synthesis of the above mentioned compounds.

Microwave-assisted, ultrasound-assisted, mechanochemical synthesis in the

combination with solvent-free synthesis and synthesis in deep eutectic solvents (DESs)

and ionic liquids (ILs) of quinolines, quinazolines and quinazolinones is described. All

mentioned green chemistry methods are gaining promising environmental and

economic benefits and are being a subject of many research these days.

Keywords: Deep eutectic solvents, Mechanochemical synthesis, Microwaveassisted synthesis, Quinazoline, Quinazolinone, Quinoline, Solvent-free synthesis, Ultrasound-assisted synthesis.

Cite as

Current Chinese Science

Anti-Cancer Agents in Medicinal Chemistry

Current Computer-Aided Drug Design

Current Bioactive Compounds

Current Medicinal Chemistry

Current Topics in Chemistry

The Natural Products Journal

Current Catalysis

Current Chinese Chemistry

Combinatorial Chemistry & High Throughput Screening

A Journey Through Water: A Scientific Exploration of The Most Anomalous Liquid on Earth

Advances in Mathematical Chemistry and Applications

Advances in Mathematical Chemistry and Applications Volume 1 (Revised Edition)

Advances in Protein and Peptide Sciences

An Account of Thermodynamic Entropy

Applications of Modern Mass Spectrometry

Applications of NMR Spectroscopy

DOI https://doi.org/10.2174/9789815039269122160004	Print ISSN 1574-0870
Publisher Name Bentham Science Publisher	Online ISSN 2212-408X

Advances in Organic Synthesis