Advances in Organic Synthesis

Volume: 16

Application of Modern Green Chemistry Methods in the Synthesis of Quinolines, Quinazolines and Quinazolinones

Author(s): Mario Komar and Maja Molnar * .

Pp: 63-115 (53)

DOI: 10.2174/9789815039269122160004

* (Excluding Mailing and Handling)


In the last few decades, there is a constant demand for novel bioactive
compounds in all areas of pharmacy and medicine, thus increasing the demands for
their design and synthesis. Quinolines, quinazolines and quinazolinones, highly
bioactive heterocyclic compounds with a nitrogen core, have been employed in many
important drugs nowadays. Their synthesis often includes an enormous amounts of
different hazardous organic solvents, catalysts, as well as energy consumption. In the
last two decades, there is a growing interest in the application of different green
chemistry methods in different research areas, including synthesis. This chapter
describes their application in the synthesis of the above mentioned compounds.
Microwave-assisted, ultrasound-assisted, mechanochemical synthesis in the
combination with solvent-free synthesis and synthesis in deep eutectic solvents (DESs)
and ionic liquids (ILs) of quinolines, quinazolines and quinazolinones is described. All
mentioned green chemistry methods are gaining promising environmental and
economic benefits and are being a subject of many research these days.

Keywords: Deep eutectic solvents, Mechanochemical synthesis, Microwaveassisted synthesis, Quinazoline, Quinazolinone, Quinoline, Solvent-free synthesis, Ultrasound-assisted synthesis.

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