Potential Nanoformulation Approaches for Delivery of HCC Therapeutic Agents

Hepatocellular carcinoma (HCC) is a major cancer type worldwide. The

major challenge with HCC is that it is usually detected at an advanced stage. After the

launch of the first drug Sorafenib against HCC in 2007, several other small molecules

and monoclonal antibody-based drugs have been launched to fight against HCC.

However, the survival rate in HCC is still very poor. This indicates that there is still a

necessity for more effective therapy or to increase the efficacy of the existing therapy.

Nanoformulation approach refers to such formulation approaches where the particle

size of individual particles or vesicles in a formulation range between 1-1000 nm. The

individual particle or vesicle could be either single drug particles or

nanosphere/nanocapsules having drug entrapped in polymer/lipid matrix or drug

connected with metal or metal oxide core. The idea of using nanoformulations for drug

targeting first came around the 1950s. Since then, countless research groups across the

world have advanced the field to the extent that several products based on the

nanoformulation approach have been launched on the market. Besides targeting,

nanoparticles can also help circumvent biopharmaceutical challenges of drugs, such as

dissolution, limited oral bioavailability issue, or formulating “hard to solubilize” types

of molecules for parenteral formulation. This chapter will review different

nanoformulation approaches that can be potentially applied for HCC therapy, their

manufacturing process, and therapeutic benefits. We will review the application of

different nanoformulation approaches for HCC specific therapeutic agents.

Keywords: Liposome, Liquid crystalline nanoparticles (LCN), Micelle, Nano lipid carrier (NLC), Nanocrystal, Nanosuspension, Polymeric nanoparticles, Solid lipid nanoparticle (SLN), Targeted therapy.

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