Modern Cancer Therapies and Traditional Medicine: An Integrative Approach to Combat Cancers

Signaling Pathways in Oncotherapy

Author(s): Sonia Thapa, Arem Qayum, Jasvinder Singh, Tenzen Yodun and Shashank K. Singh * .

Pp: 24-46 (23)

Doi: 10.2174/9789814998666121010005

* (Excluding Mailing and Handling)

Abstract

Cancer is the most dreadful disease and has significant health problems occurring worldwide. Cancer can arise from abnormal proliferation in a cell, and there are a diverse number of signaling pathways that regulate cell proliferation and its behavior. The signaling pathways contribute to the development and cellular homeostasis in cells. In diseases, especially cancer, developmental components of these pathways often become mutated or in many cases, overexpressed, which cause interruption or deregulation of cellular signaling. Cancer treatment action can target multiple signaling pathways and their molecular targets. This chapter provides an overview of the key pathways involved in tumor development and progression and components of the signaling pathways and their cross-talk associated with therapeutic implications.


Keywords: Cancer, Death Receptor, Drug Targets, Insulin-like Growth Factor Receptor, Epidermal Growth Factor Receptor, Fibroblast Growth Factor Receptor, G –Protein Coupled Receptor, Membrane Receptors, Platelet-derived Growth Factor, Receptor Tyrosine Kinase, Signaling Pathways, Targeted Therapy, Therapeutic Strategies.

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