Introduction to Molecular Genomics

Modern Genomic Implications

Author(s): Maryam Javed, Asif Nadeem and Faiz-ul Hassan

Pp: 148-173 (26)

Doi: 10.2174/9781681089256121010011

* (Excluding Mailing and Handling)

Abstract

This chapter proposes a brief description of Possible health enhancement; Genome-wide association studies (GWAS); GWAS and different case studies; Nextgeneration sequencing (NGS); Steps of Next-generation DNA sequencing; DNA library preparation, Amplification, Emulsion PCR, Bridge PCR, Sequencing; Impacts of Genomic in Future Health; Cancer: stratifying tumors for treatment; Drug prescription and development; Diagnosing and characterizing genetic disease; From disease diagnosis to personalized genetic health; Integrating genomic and clinical information; Economic benefits of genomic medicine; Targeted genome editing: a new era in modern genomics; Modifying the Genome Through Nucleases; Zinc Finger Nucleases, Transcription Activator-like Effector Nucleases, Clustered Regularly Interspaced Short Palindromic Repeats / Cas9 (CRISPR/Cas 9), Delivering the Nucleases; Application of Engineered Nucleases; Personalized Medicine; Epigenome.


Keywords: CRISPR/Cas 9, GWAS, NGS, Personalized Medicine.

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