Frontiers in Clinical Drug Research - CNS and Neurological Disorders

Volume: 9

CAR-T Cells in Brain Tumors and Autoimmune Diseases – from Basics to the Clinic

Author(s): Mansour Poorebrahim*, Niloufar Mohammadkhani, Mohammad Foad Abazari, Elham Fakhr, Isaac Quiros-Fernandez, Solmaz Sadeghi and Angel Cid-Arregui

Pp: 65-89 (25)

Doi: 10.2174/9781681089041121090005

* (Excluding Mailing and Handling)

Abstract

Chimeric antigen receptor (CAR)-T cell therapy has recently been introduced as a promising therapeutic T cell-based therapy. Autologous T cells are collected from the patient, engineered in vitro to express artificial chimeric receptors against a specific tumor antigen, and infused into the patient. The success of adoptive CAR-T cells for cancer immunotherapies, particularly in hematological malignancies, inspired researchers of the field. These armored T cells also showed a great potential to be used in the treatment of pediatric brain tumors and autoimmune diseases. In this chapter, we summarize the basics and developments of CAR-T cells from our previous review articles and then discuss the current progress in the pre-clinical and clinical application of CAR-T cells in brain tumors and autoimmune diseases.


Keywords: Adoptive cell therapy, Autoimmune disease, Brain tumor, Cancer immunotherapy, CAAR, CAR-T, Glioblastoma, Regulatory T cell, Tumor antigen.

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