Frontiers in Clinical Drug Research – Anti Allergy Agents

Volume: 4

In-Silico Approaches in Drug Discovery and Design of Anti-Allergic Agents

Author(s): Purusottam Banjare, Ajay Singh Sarthi, Jagadish Singh and Partha Pratim Roy

Pp: 94-132 (39)

DOI: 10.2174/9789811428395120040006

* (Excluding Mailing and Handling)

Abstract

The process of drug discovery is a long back episode appearing from the ancient times. The therapeutic applications of plants, mineral were recorded in ancient civilizations like Chinese, Hindus, and European. The development of the new drug from lead/hit molecules is a very expensive event considering money, manpower as well as time. The traditional approach includes the synthesis of compounds in laboratory which is a time-consuming process and their testing in in-vivo biological assays. The in silico approaches are often known as high throughput screening methods (HTS)/ virtual screening mainly applied in the early phases of drug discovery.It helps the researchers to go deep into in silico simulation prior to wet laboratory experiments. The statistics highlighted that there is a shift from 10% to 20% by the pharmaceutical industries in pharmaceutical R&D on computer modeling and simulations. In late 1990s FDA identified that poor pharmacokinetic parameters (ADME/Tox) were one of the major cause of late stage failure of drug candidates for clinical trials. In the past decade, there was a remarkable growth of computational approach in bridging the chemical and biological process in drug discovery pipeline.The advent of the arena of in silico approaches was made possible by the advancement of software and hardware computational ability and afurther increase in precision and accuracy. The incidents of allergic diseases like bronchial asthma, allergic rhinoconjunctivitis and atopic dermatitis are increasing. Drugs in this categories act through different targets like inhibitors of histaminic receptors, leukotrienes,thromboxinase-A2 inhibitors, mast cell stabilizer. In this context, the chapter tries to give emphasis on different recent targets for antiallergic agents and abrief overview on in silico methods as well as computational studies carried out for the targets in accelerating the drug discovery for the antiallergic agents for controlling the above-mentioned disease.


Keywords: ADME/T, Antiallergic Agents, HTS, in Silico.

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