Helicobacter pylori infection which is a constantly occurring disease causes damage to normal regulation and function of gastric acid. It was estimated that peptic ulcer infection was developed in about only 15% of persons that were infected with Helicobacter pylori. Burning, epigastric pain, and nocturnal pain after food intake are typical symptoms. Urea breath test, stool antigen test, or an endoscopic biopsy and ELISA may be performed as a diagnostic test for confirmation of occurrence of Helicobacter pylori infection in peptic ulcer patients. Management for peptic ulcer infection includes drug treatment and surgery.