Whooping cough is a respiratory tract infection mainly occurs in children and infants. Bordetella pertussis is bacteria that is responsible for the cough. It is a gram-negative bacteria that belong to the Cocco-bacillus group. Whooping cough is also known as Pertussis. Parents and siblings play a major role in its transmission. It is transferred from person to person. Illness, sneezing, and cough are the main symptoms. By observing the victim it can diagnose easily, by a blood test or by physical examination. However, the treatment of cough is now present in this era. Vaccination is present for treating pertussis. These vaccines are effective, but not enough efficient in their performance. Before the advent of vaccines, pertussis is an epidemic disease, but nowadays it is working against cough for treatment to some extent. More advanced techniques are trying to discover for treating and curing pertussis.