Rat-bite fever is a zoonotic infection that is caused by these two bacteria Streptobacillus moniliformis and Spirillum minus. These two bacteria cause similar but distinct infections, that are transmitted through rats bite, mucous or other feces. It is a rare disease and practices are uncommon on this infection it can be fatal if not treated on time. It is transmitted through rat’s feces, mucous of rat mouth, nose or may be transmitted through contaminated products with rats. Patients undergo fever, rashes, joint pain due to infection. Moniliform bacteria cause Arthritis. As, there is no vaccine available for Rat-bite fever, practices on development for infection treatment are on the way. Antibiotics and Antiallergens are available to cure rashes and infection. This infection can cause syndromes, so treatment on time and preventive measurement are necessary.