Recent Insights of Matrix Metalloproteinase Inhibitors in Therapeutic Applications

Pp: 73-96 (24)

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Abstract

Matrix metalloproteinases are proteolytic zinc-dependent enzymes that play a pivotal function in cell migration, proliferation, differentiation, programmed cell death, and other physiological processes. Recent studies demonstrated that the imbalance activation and inhibition of these enzymes resulted in unexpected physiological and pathological processes. Thus, it fueled the interest in matrix metalloproteinase and its inhibitors in medicinal and pharmaceutical chemists. This chapter discusses the therapeutic accomplishments of matrix metalloproteinase inhibitors in arthritis, autoimmune disease, inflammations, cancer, and cardiovascular disease. Further, the chapter discusses clinical trial implications, obstacles, and future research.

Keywords: Arthritis, Autoimmune disease, Classifications, Cancer, Cardiovascular disease, Clinical implications, Endogenous tissue inhibitors, Exogenous inhibitors, Functional roles, Inflammations, Matrix metalloproteinase, Matrix metalloproteinase inhibitors, Mechanism, Obstacles, Therapeutic accomplishments.