Even with extensive documentation on the health benefits of physical activity (PA), a part of the population does not practice enough PA to have these benefits, especially people with disabilities. People with motor disabilities tend to be less engaged in PA than their peers, even with the positive outcomes on bodily, social, functional and emotional changes promoted by PA. Therefore, the identification and knowledge of PA’s determinants, either as facilitators or barriers, for people with motor disabilities seems logical and essential. The goal of this chapter is to review the literature about these determinants and examine possible future paths. This information can contribute to conceptual changes and new interventions and policies that increase the levels of PA practice in this population subgroup and, consequently, further advance their social inclusion.