Anti-Obesity Drug Discovery and Development

Volume: 4

Anti-Obesity Molecules from Plants and their Mode of Action

Author(s): Megha Valsaraj, Navaneetha Saseendran, Arun Subash Koorapally and Anu Augustine

Pp: 197-224 (28)

Doi: 10.2174/9781681085586118040008

* (Excluding Mailing and Handling)

Abstract

Obesity is a chronic condition that is causally related to serious medical illnesses. Plants, especially those used in Ayurveda, can provide biologically active molecules and lead structures for the development of drugs with enhanced activity and reduced toxicity. Natural products, particularly medicinal plants, are believed to harbor potential anti-obesity agents that can act through various mechanisms, either by preventing weight gain, or by promoting weight loss. Their mechanisms of action include inhibition of key lipid and carbohydrate hydrolyzing and metabolizing enzymes, modification of serum lipoprotein and apolipoproteins, blockage of intestinal absorption, disruption of adipogenesis and adipogenic factors, suppression of appetite etc. The chapter gives an account of medicinal plants used in antiobesity drug formulations in Ayurveda and their mechanisms of action, like Holoptelea integrifolia, Averrhoa bilimbi, Terminalia chebula, Picrorhiza kurroa, Acorus calamus etc. The knowledge and detailed study about these plants will help to control obesity and to increase awareness on the importance of medicinal plants in addressing the issue.


Keywords: Acorus calamus, Apolipoprotein, Averrhoea bilimbi and Terminalia chebula, Cholesterol, Chylomicrons, HDL, HMGR, Holoptelea integrifolia, LCAT, LDL, LPL, Lekhaneyagana, Obesity, Picrorhiza kurroa, VLDL.

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