Bone Marrow Aspirate Concentrate and Expanded Stem Cell Applications in Orthopaedics

Ethics in the Clinical Use and Research of Stem Cells and BMAC

Author(s): Ahmed Negida, Ahmed Elgebaly, Daniel Jackson and Mohamed A. Imam

Pp: 22-35 (14)

DOI: 10.2174/9781681086491118010008

* (Excluding Mailing and Handling)


Stem cell research is rapidly progressing especially in the field of orthopaedic surgery. The processes of stem cell extraction, expansion, injection, evaluation in preclinical studies and translation into human trials are challenging. Due to the novelty and complexity of stem cell techniques, several methodological and ethical issues need to be explored. Assessment of risk versus benefit proportionality, selecting appropriate participants and determining a reliable therapeutic end point are major challenges for stem cell trials in humans. In this chapter, we are discussing ethical and methodological challenges in the clinical use and research of stem cells and Bone Marrow Aspirate Cells.

Keywords: Bone Marrow, Bone Marrow Aspirate Concentrate (BMAC), Ethics in research, Stem Cells.

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